CARDIAC HEALTH

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We are less aware that lifetime health problems you may have or occur in future due to your genes and your strengths which you are gifted by your parents.Avastu Genetics help you to recognise them and also help you to cure your genetic health problems through counselling, diet and nutrition’s. It is a onetime Investment Program includes 105 Phenotypes tests which will guide to identify your Generic Strength and protect you from your Genetics Problem throughout your life.


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Cholesterol Metabolism

Cholesterol metabolism in humans is complex. Cholesterol is either supplied from the diet (exogenous) or synthesized de novo by many cells of the body (endogenous). The major factors in the diet that may increase the blood cholesterol level are high intakes of cholesterol itself, or of saturated fats and excessive calories. The liver is one of the major sites of endogenous cholesterol synthesis. The pool of cholesterol in the liver is tightly regulated and reflects the input of cholesterol from the diet, the biosynthesis of cholesterol, the secretion and uptake of cholesterol from plasma lipoproteins, the conversion of cholesterol into bile, and the reuptake of biliary cholesterol and bile acids from the intestine to the liver. The concentration of cholesterol in the blood in fasting normal humans is the result of the metabolism of cholesterol from exogenous and endogenous sources. Environmental factors such as dietary fatty acids, and metabolic perturbations such as diabetes and obesity as well as genetic factors also influence the level of cholesterol in blood. Consequently, after several decades, hypercholesterolemia causes atherosclerotic vascular disease.

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Cholesterol Response to Calorie Restriction

Calorie restriction helped improve all factors of metabolic syndrome in people without obesity. The benefits of a calorie-restricted diet likely span beyond cardiovascular health, Hu noted, highlighting how this diet strategy is also being studied for slowing the aging process and extending lifespan.
CR results in profound and sustained beneficial effects on the major atherosclerosis risk factors, serum Tchol, LDL-C, HDL-C, TG, and BP, that usually increase with advancing age. They further show that CR provides a powerful protective effect against obesity and insulin resistance, and provide evidence for a decrease in inflammation, as reflected in extremely low CRP levels.

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Hypertension Risk

Blood pressure is the force exerted by circulating blood against the walls of the body’s arteries, the major blood vessels in the body. Hypertension is when blood pressure is too high.
Causes of High Blood Pressure
1. Smoking
2. Being overweight or obese
3. Lack of physical activity
4. Too much salt in the diet
5. Too much alcohol consumption
6. Stress
7. Older age
8. Genetics
9. Family history of high blood pressure
10. Chronic kidney disease
11. Adrenal and thyroid disorders
12. Sleep apnea
Risk Factors
1. Damage to your arteries
2. Damage to your heart
3. Enlarged left heart
4. Heart failure
5. Damage to your brain
6. Damage to your kidneys
7. Damage to your eyes

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Homocysteine Level Regulation

Homocysteine is an amino acid (a building block of protein) that is produced in the body. There has been an indication towards a significant correlation between hyperhomocysteinemia and cardiovascular disease and its complications such as heart attacks and strokes. It is believed that hyperhomocysteinemia leads to endothelial cell damage, reduction in the flexibility of vessels, and alters the process of haemostasis.
Hyperhomocysteinemia may lead to an enhancement of the adverse effects of risk factors like hypertension, smoking, lipid and lipoprotein metabolism, as well as promotion of the development of inflammation. The prevalence of hyperhomocysteinemia may vary significantly between populations, and most likely depend on age, diet, and genetic background as well.

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Hypertriglyceridemia Risk Description

Hypertriglyceridemia has many causes, including familial and genetic syndromes, metabolic disease, and drugs. Risks appear to include diet, stress, physical inactivity, and smoking. hypertriglyceridemia is associated with increased risk of cardiovascular disease, obesity, insulin resistance, diabetes, hypertension and hyperuricemia. we can help to identify as per genetic aspects favourable positively or negatively and actual cause root in your body.
Causes:
The most common reasons for hypertriglyceridemia developing are obesity, lack of physical activity, type 2 diabetes, metabolic syndrome and familial hyperlipidemia, a genetic condition that causes high triglycerides and low levels of the “good” cholesterol, HDL (high-density lipoprotein). Hypertriglyceridemia is often accompanied by low HDL levels
Symptoms :
1. Gastrointestinal pain
2. Difficulty breathing
3. Memory loss
4. Dementia
5. Xanthelasmas - yellowish deposits of fat on or around the eyelids
6. Corneal arcus - a thin, whitish or grey arc around the outer part of the cornea
7. Xanthomas - yellowish deposits of fat under the skin found on the back, chest, buttocks or proximal extremities.

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Atherosclerosis

Atherosclerosis is a hardening and narrowing of your arteries. It can put blood flow at risk as your arteries become blocked. You might hear it called arteriosclerosis or atherosclerotic cardiovascular disease. It’s the usual cause of heart attacks, strokes, and peripheral vascular disease which all together is as called Cardiovascular disease.
Signs and Symptoms:
You might not have symptoms until your artery is nearly closed or until you have a heart attack or stroke. Signs can also depend on which artery is narrowed or blocked.
Symptoms related to your coronary arteries include:
1. Arrhythmia, an unusual heartbeat
2. Pain or pressure in your upper body, including your chest, arms, neck, or jaw. This is known as Angina.
3. Shortness of breath
Symptoms related to the arteries that deliver blood to your brain include:
1. Numbness or weakness in your arms or legs
2. A hard time speaking or understanding someone who’s talking
3. Drooping facial muscles
4. Paralysis
5. Severe headache
6. Trouble seeing in one or both eyes
Symptoms related to the arteries of your arms, legs, and pelvis include:
1. Leg pain when walking
2. Numbness
Symptoms related to the arteries that deliver blood to your kidneys include:
1. High blood pressure
2. Kidney failure

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Sudden Cardiac Arrest (SCA)

Sudden cardiac arrest is the abrupt loss of heart function, breathing and consciousness. The condition usually results from an electrical disturbance in your heart that disrupts its pumping action, stopping blood flow to your body.
Sudden cardiac arrest differs from a heart attack, when blood flow to a part of the heart is blocked. However, a heart attack can sometimes trigger an electrical disturbance that leads to sudden cardiac arrest.
Symptoms:
Sudden cardiac arrest signs and symptoms are immediate and drastic and include:
1. Sudden collapse
2. No pulse
3. No breathing
4. Loss of consciousness
Causes:
A problem in your heart rhythm (arrhythmia) — the result of a problem with your heart's electrical system — is the usual cause of sudden cardiac arrest.

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Lipid Metabolism Description

Lipid metabolism is a complex process that involves multiple steps involving the dietary intake of lipids (exogenous) or the production of lipids within the body (endogenous) to degradation or transformation (catabolism) into several lipid-containing structures in the body. A brief description of metabolism related to fatty acids and cholesterol is provided below.
The dietary fat in the form of triacylglycerol (TAG), cholesterol, cholesteryl esters, and free fatty acids is absorbed by the intestine after going through various steps during digestion from mouth to intestine.

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Vasoconstriction Risk

Vasoconstriction reduces the volume or space inside affected blood vessels. When blood vessel volume is lowered, blood flow is also reduced. ... Abnormal vasoconstriction may cause or worsen high blood pressure. Chronic high blood pressure can increase your risk of heart disease and stroke, we can assist your complete prevention plans and find actual genetics response in issue

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Dilated and Hypertrophic Cardiomyopathy Risk

Cause of dilated cardiomyopathy isn't known. ... Some diseases, conditions and substances also can cause the disease, such as: Coronary heart disease, heart attack, high blood pressure, diabetes, thyroid disease, viral hepatitis and HIV. Infections, especially viral infections that inflame the heart muscle. Genetic factor also play a major role for cause of dilated and hypertrophic cardiomyopathy , we can assist your complete prevention plans and find actual genetics response related problems.

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Coronary Artery Disease Risk

Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary arteries). Plaque is made up of cholesterol deposits. Plaque buildup causes the inside of the arteries to narrow over time. This process is called atherosclerosis the factors for coronary artery disease are high LDL cholesterol, low HDL cholesterol, high blood pressure, family history, diabetes, smoking, being post-menopausal for women and being older than 45 for men, according to Fisher. Obesity may also be a risk factor. As per research it found that genetic aspects also plays major role for coronary artery disease